Constance Nebbercracker, later known as the Monster House, is the titular main antagonist of the 2006 Columbia Pictures computer-animated horror film of the same name.

Connor Shepard, also known as Concussion, is the main antagonist of the 2006 superhero film Zoom. He is the older brother of Jack Shepard/Captain Zoom who went insane after he was exposed to …

Stanley "Stan" Beals is the main antagonist of the 2006 Warner Bros. computer-animated film The Ant Bully. He is a flagitious exterminator who takes great pleasure in wiping out insects.

Francis "Frank" Costello is the main antagonist of the 2006 epic crime thriller film The Departed. An Irish-American mob boss, Costello rules over the Irish neighborhood of South Boston as its reigning …

Gary Smith, the antagonist in the 2006 video game Bully, manipulates others using intelligence and charisma. He pretends to befriend Jimmy Hopkins to use him as muscle and a scapegoat.

Ronald "Ronnie" James McGorvey is a major antagonist in the 2006 drama film Little Children. He is played by Jackie Earle Haley. Ronnie J. McGorvey is a middle-aged man living with his elderly …

William "Bill" Cox is the main antagonist in the 2006 thriller film Firewall. He was portrayed by Paul Bettany, who also portrayed Silas in The Da Vinci Code, Gangster in Gangster No. 1, and Dryden …

Mr. Walken is the main antagonist of the 2006 comedy film Little Man. He was portrayed by Chazz Palminteri, who played Mr. King in Down to Earth, Smokey in Stuart Little, and Buster in Lady and …

Dr. Marcus Kozak is the main antagonist of the 2006 live-action Disney remake The Shaggy Dog. He is the former chief executive of the "Grant and Strictland" corporation, later becoming its temporary …

The Bullies are titular supporting characters in the 2006 action-adventure video game Bully. They are a group of aggressive and often sadistic thugs, led by Russell Northrop, one of the five core cliques at …